Whitepaper

In-silico bioprocess modeling for CHO process development

Process development forces high-impact decisions from limited data — which media, feed strategies, inoculum conditions and set points are most likely to improve yield and robustness. Brute-force screening can't cover the space: even a moderate number of media variants, feed settings and inoculation strategies produces a design that's too large, too slow, and too expensive to run.

This paper describes a modeling framework that learns a compact representation of bioprocess dynamics from historical run data, then acts as a digital twin — simulating expected trajectories from planned set points alone. Trained on historical fed-batch CHO runs spanning 5–500 L, it lets teams evaluate candidate conditions in silico and take only the most informative ones to the bench.

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Speaker

Yaron David, Co-Founder and CTO of BioRaptor

Yaron David, MD, PhD,

Co-Founder and CTO, BioRaptor

You’ll  learn:

<ul><li>Why purely empirical screening and purely data-driven models both break down in small, unevenly distributed process datasets</li><li>How joint representation and dynamics learning captures process state as it evolves, not just endpoints</li><li>How the model simulates VCD, metabolites, volume and product concentration from set points alone</li><li>How to use predicted trajectories and confidence bands to prioritize a DoE and avoid low-value runs</li><li>Where the model flags uncertain regions that warrant more experimental data</li></ul>

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